Genetic developments in autoimmune thyroid disease: an evolutionary process
نویسندگان
چکیده
منابع مشابه
New Genetic Insights from Autoimmune Thyroid Disease
The autoimmune thyroid diseases (AITDs) (Graves' disease and Hashimoto's thyroiditis) are complex genetic diseases which most likely have more than 20 genes contributing to the clinical phenotypes. To date, the genes known to be contributing fall into two categories: immune regulatory genes (including HLA, CTLA4, PTPN22, CD40, CD25, and FCRL3) and thyroid-specific genes (TG and TSHR). However, ...
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Autoimmune thyroid disease is frequently accompanied by other organ-specific and non-organ-specific diseases, most likely because there is sharing of genetic and possibly environmental susceptibility factors. These associations are well recognized in the autoimmune polyglandular syndromes; autoimmune thyroid disease is one of the three major endocrinopathies in the type 2 syndrome and occurs in...
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Autoimmune diseases are a group of disorders in which the immune system dysfunctions and attacks host tissues. Although the pathogenesis of autoimmune thyroid disease has not been elucidated, there are several factors that have been associated with the disorder. Factors include genetic predisposition, nutrient deficiencies, use of certain medications affecting thyroid function, and environmenta...
متن کاملAutoimmune thyroid disease
Autoimmune thyroid disease (AITD) is a disease in which the body interprets the thyroid glands and its hormone products triiodothyronine (T3), thyroxine (T4) and thyroidstimulating hormone (TSH) as threats, therefore producing special antibodies that target the thyroid’s cells, thereby destroying it. It presents with hypothyroidism (low production of thyroid hormone) or hyperthyroidism (excessi...
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ژورنال
عنوان ژورنال: Clinical Endocrinology
سال: 2008
ISSN: 0300-0664,1365-2265
DOI: 10.1111/j.1365-2265.2007.03075.x